Human activity can have negative impacts on Southern Alligator Lizard. First, as we have learned in the class, forest fires now occur in an unnatural way due to inadequate human intervention. Previously mild ground fires come to verge on crown fire nowadays, which destroys the homes of the lizard. At the same time, commercial and residential development tends to take away the home of lizard for real estates. The loss of habitats poses a potential threat to Southern Alligator Lizard. Moreover, undiscriminating killing can also cause the decline in their population. Because of the strong adaptive capacity of Southern Alligator Lizard, they appear in cities or other human resident areas. When people are doing disinsection, the toxin will be intaken by the lizard in various ways, leading to their perishment.

Not only human action impact the Southern Alligator Lizard, our pets also influence them. Introduced species, including cats and dogs, may kill Southern Alligator Lizard. The resultant declination in lizard population leads to an increase in unwanted garden and yard pest insects, which prompts people to use more pesticides – a viscious circle might begin in this way.

Despite all the influences of human activity and urbanization, there is no obvious evidence that the well-being of Southern Alligator Lizard in California is substantially threatened. Generally it is regarded that human impacts on the lizard is insignificant.